Ivermectin 12 Mg

Description

What is Ivermectin 12 Mg?

Ivermectin 12 mg is a higher-strength oral tablet formulation of the antiparasitic agent Ivermectin. It belongs to a class of medications known as anthelmintics, which are used to treat infections caused by parasitic worms (helminths).

Originally developed from a bacterium discovered in soil samples, Ivermectin has had a profound impact on global health, particularly in the fight against neglected tropical diseases. Its discovery earned scientists William C. Campbell and Satoshi Ōmura the Nobel Prize in Physiology or Medicine in 2015.

The 12 mg tablet is typically used for larger individuals or for specific parasitic infections where a higher single dose is required for effective treatment.

Main Ingredients

The active ingredient in each tablet is Ivermectin 12 mg. The formulation also contains inactive ingredients (excipients) that form the tablet itself. These can vary by manufacturer but commonly include substances like microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, and magnesium stearate. These inactive components are generally inert and help in the tablet’s stability, dissolution, and absorption.

Manufacturer

Ivermectin 12 mg is manufactured by Healing Pharma, a pharmaceutical company based in India. Healing Pharma produces a wide range of generic medications and exports them to various countries around the world.

What are the Benefits of taking Ivermectin 12 Mg?

The primary and unequivocal benefit of Ivermectin 12 Mg is its potent efficacy against a range of parasitic infections. Its benefits are most significant in:

• Eradicating Parasitic Worms: It is highly effective at killing the microscopic larvae of certain parasites and paralyzing and killing adult worms, thereby clearing the infection.

• Improving Quality of Life: By eliminating debilitating parasites, it relieves symptoms such as intense itching, skin lesions, blindness (in the case of river blindness), and general malaise.

• Mass Drug Administration (MDA): Its safety profile in single-dose regimens has made it a cornerstone of public health programs, donated by Merck through the Mectizan Donation Program, which has helped control and eliminate river blindness and lymphatic filariasis in many endemic regions.

What is Ivermectin 12 Mg Used For?

✅ Approved Uses (FDA & WHO Approved):

1. Strongyloidiasis: An intestinal infection caused by the worm Strongyloides stercoralis.

2. Onchocerciasis (River Blindness): An infection caused by the worm Onchocerca volvulus, transmitted by black flies, which can cause severe itching and blindness.

3. Lymphatic Filariasis (Elephantiasis): Caused by Wuchereria bancrofti and other filarial worms, often used in combination with other medications like albendazole.

What is the right dosage of Ivermectin 12 Mg?

Dosage is typically calculated based on micrograms per kilogram of body weight (mcg/kg).

• For Strongyloidiasis: The standard dose is 200 mcg/kg as a single dose. For a 60 kg (132 lb) person, this would be one 12 mg tablet. Treatment may need to be repeated.

• For Onchocerciasis: The standard dose is 150 mcg/kg as a single dose. For an 80 kg (176 lb) person, this would be one 12 mg tablet. Treatment is usually repeated every 6 to 12 months until the patient is asymptomatic.

Your doctor will determine the correct number of tablets and the frequency of dosing.

How to Take Ivermectin 12 Mg

• Timing: Take Ivermectin on an empty stomach, at least 1 hour before a meal or 2 hours after a meal, with a full glass of water. This maximizes its absorption.

• Adherence: Follow your doctor’s instructions precisely. Do not take more or less than prescribed.

• Completion: Even if you start to feel better, complete the course as directed.

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How Long Does it Take to Start Working?

Ivermectin begins to work quickly after ingestion. The drug’s peak concentration in the bloodstream occurs within approximately 4 to 5 hours. However, the time it takes to notice a reduction in symptoms (like itching) depends on the infection being treated. For conditions like strongyloidiasis, symptom improvement may occur within days. For river blindness, the reduction in skin microfilariae is rapid, but the prevention of blindness is a long-term outcome of repeated annual or semi-annual dosing.

Side Effects 💊

Like all medicines, Ivermectin can cause side effects, though not everyone gets them. Many are mild and temporary.

Common Side Effects:

• Dizziness

• Nausea, diarrhea

• Loss of appetite

• Constipation

• Itchy skin or skin rash

• Fatigue

These often resolve on their own as your body adjusts to the medication.

Less Common but More Serious Side Effects:

• Worsening of Onchocerciasis Symptoms: A complex called the Mazzotti reaction can occur, involving fever, swollen glands, joint pain, and intense itching. This is actually a sign that the drug is killing the parasites.

• Orthostatic Hypotension: A sudden drop in blood pressure upon standing up, leading to dizziness or fainting.

• Fast heart rate (tachycardia)

• Eye-related problems: Pain, redness, swelling, or vision changes.

• Severe skin rash.

• Signs of an allergic reaction: Hives, difficulty breathing, swelling of the face, lips, tongue, or throat.

Safety Advice for Ivermectin 12 🛡️

Dos for Patients:

• DO inform your doctor about all your medical conditions, especially liver disease, kidney disease, or asthma.

• DO provide a complete list of all other medications, supplements, and vitamins you are taking.

• DO inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Ivermectin’s use in pregnancy is typically avoided unless the potential benefit justifies the potential risk.

• DO get a confirmed diagnosis from a healthcare professional before taking any medication.

Don’ts for Patients:

• DO NOT take Ivermectin for COVID-19 unless as part of a clinical trial supervised by a doctor.

• DO NOT use formulations intended for animals (e.g., horse paste). Veterinary products are highly concentrated and can contain ingredients toxic to humans.

• DO NOT share your medication with anyone else.

• DO NOT take a double dose to make up for a missed one.

Storage

• Store Ivermectin tablets at room temperature (15°C to 30°C or 59°F to 86°F).

• Keep them in their original container, away from light and moisture.

• Keep all medications out of the reach of children and pets.

FAQs ❓

1. Can I take Ivermectin 12 mg for COVID-19?

No. There is no conclusive evidence from major clinical trials that Ivermectin is effective for preventing or treating COVID-19. Leading global health authorities strongly advise against it due to a lack of benefit and potential for harm.

2. Is Ivermectin an antibiotic?

No. Antibiotics fight bacterial infections. Ivermectin is an antiparasitic agent that fights infections caused by worms and other parasites.

3. Can I cut the 12 mg tablet in half?

You should only do this if your doctor or pharmacist has instructed you to. Some tablets are scored for easy splitting, while others are not and may crumble.

4. What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take two doses to make up for a missed one.

5. Can I drink alcohol while taking Ivermectin?

It is generally recommended to avoid alcohol as it may increase the risk of certain side effects like dizziness and drowsiness.

6. Is Ivermectin safe for children?

Ivermectin is used in children, but the dosage is carefully calculated based on the child’s weight. It should only be given under the direction of a pediatrician.

7. How does Ivermectin work?

It works by binding to certain channels in the nerve and muscle cells of parasites, leading to increased cell permeability, paralysis, and death of the parasite. It has a much weaker effect on these channels in humans, which contributes to its safety when dosed correctly.

8. Can Ivermectin cause liver damage?

Ivermectin is generally not considered highly toxic to the liver. However, in cases of significant overdose, liver injury can occur. Your doctor may monitor your liver function if you have pre-existing liver disease.

9. Is Ivermectin the same as Fenbendazole?

No. While both are antiparasitic drugs used in both human and veterinary medicine, they are chemically different and target different types of parasites.

10. What should I do in case of an overdose?

An overdose can be dangerous, causing symptoms like severe dizziness, nausea, vomiting, and low blood pressure.

11. Are there any long-term side effects of taking Ivermectin?

When used as directed for approved parasitic infections (typically one or a few doses), long-term side effects are rare. The long-term safety of repeated, frequent dosing (as has been incorrectly promoted for COVID-19) is not well-established and is not recommended.